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pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can cut down panobinostat degrees by ~70% and lead to cure failure.pentobarbital will minimize the extent or outcome of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importanc